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Cheap Flights from Panama City to Guayaquil

Popular airlines from Panama City to Guayaquil

Choose from 1 carriers that fly from Panama City to Guayaquil, including avianca, Enjoy the cheapest tickets on this route with Copa Airlines.
avianca logo avianca

Find direct flights from Panama City to Guayaquil within the next three months. Book one-way flights from S$ 232 or return tickets from S$ 459.

      • Cheapest nonstop
        PTY 11:19
        2h 17m
        Direct
        GYE 13:36
        Panama City - Guayaquil | Sat, Nov 22 | Copa Airlines
        GYE 14:35
        2h 11m
        Direct
        PTY 16:46
        Guayaquil - Panama City | Thu, Nov 27 | Copa Airlines
        S$ 459 S$ 727
        37% OFF
        37% OFF
        S$ 727 S$ 459
      • PTY 09:02
        2h 16m
        Direct
        GYE 11:18
        Panama City - Guayaquil | Tue, Dec 9 | Copa Airlines
        GYE 12:20
        2h 12m
        Direct
        PTY 14:32
        Guayaquil - Panama City | Thu, Dec 11 | Copa Airlines
        S$ 493 S$ 727
        32% OFF
        32% OFF
        S$ 727 S$ 493
      • PTY 21:40
        2h 15m
        Direct
        GYE 23:55
        Panama City - Guayaquil | Thu, Nov 13 | Copa Airlines
        GYE 18:37
        2h 6m
        Direct
        PTY 20:43
        Guayaquil - Panama City | Thu, Nov 20 | Copa Airlines
        S$ 573 S$ 727
        21% OFF
        21% OFF
        S$ 727 S$ 573
      • PTY 09:45
        4h 45m
        1 stop
        GYE 14:30
        Panama City - Guayaquil | Sat, Nov 22 | avianca
        GYE 18:55
        6h 5m
        1 stop
        PTY 01:00
        Guayaquil - Panama City | Thu, Nov 27 | avianca
        S$ 419
        42% OFF
        S$ 727 S$ 419
      • PTY 02:55
        14h 50m
        1 stop
        GYE 17:45
        Panama City - Guayaquil | Tue, Dec 9 | avianca
        GYE 18:55
        13h 55m
        1 stop
        PTY 08:50
        Guayaquil - Panama City | Thu, Dec 11 | avianca
        S$ 428
        41% OFF
        S$ 727 S$ 428
      • PTY 09:45
        4h 45m
        1 stop
        GYE 14:30
        Panama City - Guayaquil | Thu, Nov 13 | avianca
        GYE 18:55
        13h 55m
        1 stop
        PTY 08:50
        Guayaquil - Panama City | Thu, Nov 20 | avianca
        S$ 434
        40% OFF
        S$ 727 S$ 434
      • PTY 17:50
        7h 15m
        1 stop
        GYE 01:05
        Panama City - Guayaquil | Mon, Dec 1 | avianca
        GYE 18:55
        5h 45m
        1 stop
        PTY 00:40
        Guayaquil - Panama City | Fri, Dec 5 | avianca
        S$ 441
        39% OFF
        S$ 727 S$ 441
      • PTY 02:55
        20h 40m
        1 stop
        GYE 23:35
        Panama City - Guayaquil | Mon, Nov 17 | avianca
        GYE 10:25
        6h 30m
        1 stop
        PTY 16:55
        Guayaquil - Panama City | Sat, Nov 22 | avianca
        S$ 547
        25% OFF
        S$ 727 S$ 547
      • PTY 17:50
        15h 25m
        1 stop
        GYE 09:15
        Panama City - Guayaquil | Fri, Nov 14 | avianca
        GYE 09:05
        23h 45m
        1 stop
        PTY 08:50
        Guayaquil - Panama City | Tue, Nov 18 | avianca
        S$ 547
        25% OFF
        S$ 727 S$ 547
      • PTY 11:17
        2h 17m
        Direct
        GYE 13:34
        Panama City - Guayaquil | Mon, Dec 1 | Copa Airlines
        GYE 15:35
        17h 15m
        1 stop
        PTY 08:50
        Guayaquil - Panama City | Fri, Dec 5 | avianca
        S$ 582
        20% OFF
        S$ 727 S$ 582
      • PTY 13:00
        17h 25m
        1 stop
        GYE Invalid Date
        Panama City - Guayaquil | Sat, Nov 15 | Normal Airline
        GYE 15:00
        6h
        Direct
        PTY 16:00
        Guayaquil - Panama City | Mon, Nov 17 | Normal Airline
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Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Flying from Panama City to Guayaquil

The distance between Panama City and Guayaquil is about 1,237.56km. It takes around 2 hours 17 minutes on average to fly from Panama City to Guayaquil. The most popular month to Guayaquil is January. The off-season for travel is October.

Cheapest one-way flight priceS$ 195
Cheapest return ticket priceS$ 419
Off-season for travelOctober
Peak season for travelJanuary
Flight distance1,237.56km
Average flight time2 hours 17 minutes
Popular airlineavianca

Cheapest time to fly from Panama City to Guayaquil

The cheapest time for Panama City to Guayaquil flights: Nov 30 to Dec 7 — one way flight prices from S$ 195.

Cheapest flights
From price
Search
  • 916
  • 1623
  • 2330

  • Dec

    307
  • 714
  • 1421
  • 2128

  • Jan

    284
  • 411
  • 1118
  • 1825

  • Feb

    251
Displayed prices are calculated based on the lowest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • Which airlines offer flights from Panama City to Guayaquil?

    At the moment, several airlines serve connecting flights from Panama City to Guayaquil, including: avianca Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • It takes about 2 hours 17 minutes to fly from Panama City (PTY) to Guayaquil (GYE).
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Panama City to Guayaquil is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • The cheapest months to fly from Panama City to Guayaquil is October, when demand for travel is lower.
  • After crunching the numbers on our November flight calendar, it's currently cheapest to fly from Panama City to Guayaquil on November 26, 2025 with avianca, with prices starting at S$ 209.
  • You can land at any one of the following hubs in Guayaquil, with Tocumen International Airport to Jose Joaquin De Olmedo International Airport (PTY-GYE) is by far the most common option on this route: Jose Joaquin De Olmedo International Airport (GYE).
  • The time difference between Guayaquil and Panama City is 0h.
  • Tickets can only be changed or cancelled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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